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For biologics, such as insulin, size is a problem, as they are often too large to be absorbed by the GI tract. Researchers in Denmark are hoping that they may have a solution to improve oral drug delivery – by utilizing micrometer-sized devices. These small devices are containers the size of a sugar grain that consist of biodegradable polymers. They are equipped with lids that make sure that they only open at the exact site where they are intended to.
Delivering drugs with small devices
There are many challenges to overcome when delivering a drug orally. Getting the drug to survive the low pH of the ventricle and being released at the correct site in the gastrontestinal tract are two of them.